Best Place to Buy Metformin Online Without Prescription in Australia, Canada, and the UK
Buy metformin online (also sold under the brand name Glucophage) is a medication prescribed for the management of type-2 diabetes. Buy Metformin Online
Metformin reduces the amount of sugar released by your liver and improves the way your body handles insulin – the hormone produced by the pancreas that regulates blood sugar.
It is usually prescribed as 500mg or 850mg standard-release tablets (available to buy from HealthExpress in 84 or 168 pill packages). However, you may be recommended a modified-release (MR) version (in 500mg, 750mg and 1000mg dosages).
Your doctor will determine which is the best option for you. You should first be diagnosed with diabetes and prescribed treatment by a regular doctor before you can buy Metformin online.
You should combine this treatment with a healthy diet and exercise routine.
Please note, this medication is only prescribed for type-2 diabetes. If you suffer from type-1 diabetes, please consult your doctor for other treatment.
Diabetes is a common metabolic condition that causes high blood sugar levels. It can result in symptoms like excessive thirst and hunger, fatigue, and frequent urination and cause serious complications if left untreated.
Metformin contains the active ingredient metformin hydrochloride. As a biguanide medication, it helps your body respond more effectively to the hormone insulin that is produced by the pancreas. It could be that you produce less insulin or that you have grown insensitive to its effects.
Simultaneously, Metformin also reduces the amount of glucose that is produced by the liver.
These combined effects aid your body in regulating blood sugar levels.
When taking this medication, it is important to also maintain a healthy diet and exercise frequently.
Always take the medication exactly as it has been prescribed to you. If you are uncertain about any instructions, consult the patient information leaflet (PIL) or contact your doctor. Buy Metformin Online
When taking any version of Metformin:
- you should not exceed the prescribed daily dosage
- you should take each tablet with food
- take tablets whole – do not crush or break them
- you should visit your doctor regularly to have your blood sugar levels and your kidney function tested
- this medication should not be used as a substitute for an exercise and diet regime
- if you forget to take a dose, do not take a double dose – continue the course as normal
metformin tablets
Metformin is a drug approved by the U.S. Food and Drug Administration as a prescription medication to treat diabetes. This medication is used to decrease hepatic (liver) glucose production, decrease GI glucose absorption and increase target cell insulin sensitivity. This medication is a treatment indicated as an adjunct to diet, exercise, and lifestyle changes such as weight loss to improve glycemic (blood sugar) control in adults with type 2 diabetes. Many patients with type 2 diabetes will eventually need to take insulin by injection. Metformin does not cause weight gain.
About Type 2 Diabetes
Type 2 diabetes (also known as adult-onset or non-insulin-dependent diabetes) is the most common form of diabetes. Type 2 diabetes is a condition in which the body does not process insulin properly, resulting in elevated blood sugar (blood glucose). Insulin is a hormone that is produced in the pancreas. Type 2 diabetes is diagnosed more often in people who are overweight or obese, and who are not physically active. Patients with diabetes should also note that a healthy weight improves cholesterol levels and overall health. Insulin resistance is a condition that is commonly seen in type 2 diabetes, where it becomes difficult for the body to use the insulin that is produced. Certain genes that affect insulin production rather than insulin resistance are risk factors for developing type 2 diabetes. Family history of diabetes is a risk factor, and people of certain races or ethnicities are at higher risk. Abnormal glucose production by the liver can also lead to elevated blood sugar (glucose) levels.
Metformin is available under the following different brand names: Glucophage, Glucophage XR, Fortamet, Glumetza, and Riomet.
WHAT ARE THE DOSAGES?
Dosages of Metformin Should Be Given As Follows:
Adult Dosage Forms & Strengths for Diabetes
- Tablet, immediate-release
- 500 mg
- 850 mg
- 1000 mg
- Extended-release tablet
- 500 mg
- 750 mg
- 1000 mg
- Oral solution
- 500 mg
- 750 mg
- 1000 mg
Pediatric Dosage Forms & Strengths for Diabetes
- Tablet, immediate-release
- 500 mg
- 850 mg
- 1000 mg
- Extended-release Tablet
- 500 mg
- 750 mg
- 1000 mg
- Oral solution
- 500 mg
- 750 mg
- 100 mg
Dosage Considerations
For Adults With Type 2 Diabetes Mellitus
- Monotherapy or with sulfonylurea
- Immediate-release tablet or solution
- Initial dose: 500 mg orally every 12 hours or 850 mg orally once/day with meals; increase every two weeks
- Maintenance doses: 1500-2550 mg/day taken orally divided once every 8-12hr with meal
- Not to exceed 2550 mg/day
- Extended-release
- Glucophage XR: 500 mg orally once/day with dinner; titrate by 500 mg/day each week; not to exceed 2000 mg/day
- Fortamet: 500-1000 mg orally once/day; titrate by 500 mg/day each week; not to exceed 2500 mg/day
- Glumetza: 1000 mg orally once/day; titrate by 500 mg/day each week; not to exceed 2000 mg/day
For Prevention of Type 2 Diabetes
- 850 mg by mouth every day
- Target dosing: 850 mg orally every 12 hours
- Dosage Modifications
- Hepatic (liver) impairment: Avoid use; risk of lactic acidosis.
- Renal (kidney) impairment
- Obtain eGFR before starting metformin
- eGFR less than 30 mL/min/1.73 m²: Contraindicated
- eGFR 30-45 mL/min/1.73 m²: Not recommended to initiate treatment
- Monitor eGFR at least annually or more often for those at risk for renal impairment (e.g., elderly)
- If eGFR falls below 45mL/min/1.73 m² while taking metformin, health risks and benefits of continuing therapy should be evaluated
- If eGFR falls below 30 mL/min/1.73 m²: while taking metformin, discontinue the drug
- Polycystic Ovary Syndrome (Orphan)
- Orphan designation for the treatment of pediatric polycystic ovary syndrome
Pediatric Dosage Considerations
Type 2 Diabetes Mellitus
Immediate-release (10-16 years)
- Initial: 500 mg orally every 12 hours
- Maintenance: Titrate once/week by 500 mg; no more than 2000 mg/day in divided doses
Immediate-release (17 years of age and older)
- Initial dose: 500 mg orally every 12 hours or 850 mg orally once/daily with meals; increase every two weeks
- Maintenance doses: 1500-2550 mg/day orally divided once every 8-12hr with meal
- No more than 2550 mg/day
Extended-release (under 17 years of age)
- Safety and efficacy not established
Extended-release (17 years of age and older)
- Glucophage XR: 500 mg orally once/daily with dinner; titrate by 500 mg/day once each week; not to exceed 2000 mg/day
- Fortamet: 500-1000 mg orally once/daily; titrate by 500 mg/day once each week; not to exceed 2500 mg/day
Dosage Modifications of Medication
Renal impairment (Poor kidney function)
- Obtain eGFR before initiating metformin
- eGFR less than 30 mL/min/1.73 m²: Contraindicated
- eGFR 30-45 mL/min/1.73 m²: Initiating not recommended
- Obtain GFR at least annually in all patients taking metformin; assess eGFR more frequently in patients at increased risk for renal impairment (e.g., elderly)
- If eGFR falls to less than 45 mL/min/1.73 m² during treatment: Assess the benefits and risks of continuing treatment
- If eGFR falls to less than 30 mL/min/1.73 m² during treatment: Discontinue
Geriatric Dosage
Elderly patients with diabetes are more likely to have decreased renal function with the use of this drug; contraindicated in patients with renal impairment, carefully monitor renal function in the elderly and use with caution as age increases.
Not for use in patients over 80 years unless normal renal function established initial and maintenance dosing of metformin should be conservative in patients with advanced age due to the potential for decreased renal function in this population.
WHAT ARE SIDE EFFECTS ASSOCIATED WITH USING METFORMIN?
Side effects of metformin include:
- physical weakness (asthenia)
- diarrhea
- gas (flatulence)
- symptoms of weakness, muscle pain (myalgia)
- upper respiratory tract infection
- low blood sugar (hypoglycemia)
- abdominal pain (GI complaints), lactic acidosis (rare)
- low blood levels of vitamin B-12
- nausea
- vomiting
- chest discomfort
- chills, dizziness
- bloating/abdominal distention
- constipation
- heartburn
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
WHAT OTHER DRUGS INTERACT WITH METFORMIN?
If your doctor has directed you to use this medication for diabetes, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.
Severe Interactions of Metformin include:
There are no severe interactions from the use of metformin.
Serious Interactions of Metformin include:
- Contrast media (iodinated)
- Ethanol
- Ioversol
Drug Interactions with Metformin are:
- Metformin has moderate interactions with at least 74 different drugs.
- Metformin has mild interactions with at least 87 different drugs.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.
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