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Buy Ozempic online without prescription. Ozempic is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus Buy Ozempic Online without Prescription with Credit Card. Limitations of Use OZEMPIC is not recommended as first-line therapy for patients who have inadequate glycemic control on diet and exercise because of the uncertain relevance of rodent C-cell tumor findings to humans [see Warnings and Precautions. OZEMPIC has not been studied in patients with a history of pancreatitis. Consider other antidiabetic therapies in patients with a history of pancreatitis. OZEMPIC is not a substitute for insulin.
INDICATIONS AND USAGE
OZEMPIC is not indicated for use in patients with type 1 diabetes mellitus or for the treatment of patients with diabetic ketoacidosis, as it would not be effective in these settings. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Start OZEMPIC with a 0.25 mg subcutaneous injection once weekly for 4 weeks. The 0.25 mg dose is intended for treatment initiation and is not effective for glycemic control. After 4 weeks on the 0.25 mg dose, increase the dosage to 0.5 mg once weekly. If additional glycemic control is needed after at least 4 weeks on the 0.5 mg dose, the dosage may be increased to 1 mg once weekly. Ozempic For Sale in Malaysia.
The maximum recommended dosage is 1 mg once weekly. Administer OZEMPIC once weekly, on the same day each week, at any time of the day, with or without meals. The day of weekly administration can be changed if necessary as long as the time between two doses is at least 2 days (>48 hours). Buy Ozempic Online without Prescription with Credit Card.
What is Ozempic and how is it used?
Ozempic is a prescription medicine used to treat the symptoms of Type 2 Diabetes Mellitus. Ozempic may be used alone or with other medications.
Ozempic belongs to a class of drugs called Antidiabetics, Glucagon-like Peptide-1 Agonists.
It is not known if Ozempic is safe and effective in children younger than 18 years of age.
What are the possible side effects of Ozempic?
Ozempic may cause serious side effects including:
- a lump in the neck,
- difficulty swallowing,
- shortness of breath,
- difficulty breathing,
- upper abdominal pain,
- blurred vision,
- spots or dark strings floating in your vision,
- fluctuating vision,
- vision loss,
- dark or empty areas in your vision,
- fast heartrate,
- decreased urination,
- swelling in your legs, ankles, or feet,
- itching, and
Get medical help right away, if you have any of the symptoms listed above.
The most common side effects of Ozempic include:
- abdominal pain, and
Tell the doctor if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Ozempic. For more information, ask your doctor or pharmacist.
Call your doctor for medical advice about side effects.
RISK OF THYROID C-CELL TUMORS
- In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether OZEMPIC causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined.
- OZEMPIC is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk for MTC with the use of OZEMPIC and inform them of symptoms of thyroid tumors (e.g. a mass in the neck, dysphagia, dyspnea, persistent hoarseness). Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with OZEMPIC.
OZEMPIC (semaglutide) injection, for subcutaneous use, contains semaglutide, a human GLP-1 receptor agonist (or GLP-1 analog). The peptide backbone is produced by yeast fermentation. The main protraction mechanism of semaglutide is albumin binding, facilitated by modification of position 26 lysine with a hydrophilic spacer and a C18 fatty di-acid. Furthermore, semaglutide is modified in position 8 to provide stabilization against degradation by the enzyme dipeptidyl-peptidase 4 (DPP-4). A minor modification was made in position 34 to ensure the attachment of only one fatty di-acid. The molecular formula is C187H291N45O59 and the molecular weight is 4113.58 g/mol.
OZEMPIC is a sterile, aqueous, clear, colorless solution. Each pre-filled pen contains a 1.5 mL solution of OZEMPIC equivalent to 2 mg semaglutide. Each 1 mL of OZEMPIC solution contains 1.34 mg of semaglutide and the following inactive ingredients: disodium phosphate dihydrate, 1.42 mg; propylene glycol, 14.0 mg; phenol, 5.50 mg; and water for injections. OZEMPIC has a pH of approximately 7.4. Hydrochloric acid or sodium hydroxide may be added to adjust pH.
OZEMPIC is indicated:
- as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
- to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction or non-fatal stroke) in adults with type 2 diabetes mellitus and established cardiovascular disease.
Limitations Of Use
- OZEMPIC has not been studied in patients with a history of pancreatitis. Consider other antidiabetic therapies in patients with a history of pancreatitis.
- OZEMPIC is not indicated for use in patients with type 1 diabetes mellitus.
The following serious adverse reactions are described below or elsewhere in the prescribing information:
- Risk of Thyroid C-cell Tumors
- Diabetic Retinopathy Complications
- Hypoglycemia with Concomitant Use of Insulin Secretagogues or Insulin
- Acute Kidney Injury
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Pool Of Placebo-Controlled Trials
The data in Table 1 are derived from 2 placebo-controlled trials (1 monotherapy trial and 1 trial in combination with basal insulin) in patients with type 2 diabetes. These data reflect exposure of 521 patients to OZEMPIC and a mean duration of exposure to OZEMPIC of 32.9 weeks. Across the treatment arms, the mean age of patients was 56 years, 3.4% were 75 years or older and 55% were male. In these trials 71% were White, 7% were Black or African American, and 19% were Asian; 21% identified as Hispanic or Latino ethnicity. At baseline, patients had type 2 diabetes for an average of 8.8 years and had a mean HbA1c of 8.2%. At baseline, 8.9% of the population reported retinopathy. Baseline estimated renal function was normal (eGFR ≥90 mL/min/1.73m2) in 57.2%, mildly impaired (eGFR 60 to 90 mL/min/1.73m2) in 35.9% and moderately impaired (eGFR 30 to 60 mL/min/1.73m2) in 6.9% of patients.
Pool Of Placebo- And Active-Controlled Trials
The occurrence of adverse reactions was also evaluated in a larger pool of patients with type 2 diabetes participating in 7 placebo- and active-controlled glycemic control trials including two trials in Japanese patients evaluating the use of OZEMPIC as monotherapy and add-on therapy to oral medications or insulin. In this pool, a total of 3150 patients with type 2 diabetes were treated with OZEMPIC for a mean duration of 44.9 weeks. Across the treatment arms, the mean age of patients was 57 years, 3.2% were 75 years or older and 57% were male. In these trials, 60% were White, 6% were Black or African American, and 31% were Asian; 16% identified as Hispanic or Latino ethnicity. At baseline, patients had type 2 diabetes for an average of 8.2 years and had a mean HbA1c of 8.2%. At baseline, 7.8% of the population reported retinopathy. Baseline estimated renal function was normal (eGFR ≥90 mL/min/1.73m2) in 63.1%, mildly impaired (eGFR 60 to 90 mL/min/1.73m2) in 34.3%, and moderately impaired (eGFR 30 to 60 mL/min/1.73m2) in 2.5% of the patients.
Dosage Forms And Strengths
Injection: clear, colorless solution available in 3 pre-filled, disposable, single-patient-use pens:
|Dose per Injection||Use For||Total Strength per Total Volume||Strength per mL|
|0.25 mg 0.5 mg||Initiation Maintenance||2 mg / 1.5 mL||1.34 mg/mL|
|1 mg||Maintenance||2 mg / 1.5 mL||1.34 mg/mL|
|1 mg||Maintenance||4 mg / 3 mL||1.34 mg/mL|
Storage And Handling
Injection: clear, colorless solution of 1.34 mg/mL of semaglutide available in pre-filled, disposable, singlepatient- use pens in the following packaging configurations:
|Dose per Injection||Use For||Total Strength per Total Volume||Doses per Pen||Carton Contents||NDC|
|0.25 mg||Initiation||2 mg / 1.5 mL||4 doses of 0.25 mg and 2 doses of 0.5 mg
4 doses of 0.5 mg
|1 pen 6 NovoFine® Plus needles||0169-4132-12|
|1 mg||Maintenance||2 mg / 1.5 mL||2 doses of 1 mg||2 pens 4 NovoFine® Plus needles||0169-4136-02|
|1 mg||Maintenance||4 mg / 3 mL||4 doses of 1 mg||1 pen 4 NovoFine®Plus needles||0169-4130-13|
Each OZEMPIC pen is for use by a single patient. An OZEMPIC pen must never be shared between patients, even if the needle is changed.
Prior to first use, OZEMPIC should be stored in a refrigerator between 36°F to 46°F (2°C to 8°C) (Table 9). Do not store in the freezer or directly adjacent to the refrigerator cooling element. Do not freeze OZEMPIC and do not use OZEMPIC if it has been frozen.
After first use of the OZEMPIC pen, the pen can be stored for 56 days at controlled room temperature (59°F to 86°F; 15°C to 30°C) or in a refrigerator (36°F to 46°F; 2°C to 8°C). Do not freeze. Keep the pen cap on when not in use. OZEMPIC should be protected from excessive heat and sunlight.
Always remove and safely discard the needle after each injection and store the OZEMPIC pen without an injection needle attached. Always use a new needle for each injection.
The storage conditions are summarized in Table 9:
Table 9. Recommended Storage Conditions for the OZEMPIC Pen
|Prior to first use||After first use|
|Refrigerated 36°F to 46°F (2°C to 8°C)||Room Temperature 59°F to 86°F (15°C to 30°C)||Refrigerated 36°F to 46°F (2°C to 8°C)|
|Until expiration date||56 days|
Manufactured by: Novo Nordisk A/S, DK-2880
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